Guest post by "JD" Alice is Ralph Cramden's wife in the old show "The Honeymooners." She used to heckle poor Ralph relentlessly, and he'd respond with that "to the moon" bit, but of course he'd never do anything to hurt her because he loved her dearly.
Alice was played by Agnes Moorehead and Ralph was played by Jackie Gleason, who made "to the moon!" a household phrase in the late 1950's and 1960's... I think. Going by memory here. For exact references... Google!